★AHNAK核蛋白(2) AHNAK nucleoprotein FERM和PDZ域(4) FERM and PDZ domain;FRMPD HtrA丝氨酸肽酶(4) HtrA serine peptidase LIMK激酶(4) LIMK/TESK kinase family ★lin-7同源物(3) lin-7 homolog NHERF家族PDZ支架蛋白(4) NHERF family PDZ scaffold proteins;NHERF ★numb蛋白配体X(2) ligand of numb-protein X;LNX ★par-6家族细胞极性调节物(3) par-6 family cell polarity regulator;PARD6 PDZ和LIM域(2) PDZ and LIM domain ★PDZ域GIPC(3) PDZ domain GIPC family ★PDZ域环指3/4(2) PDZ domain containing ring finger 3/4;PDZRN3/4 ★SH3和多个锚蛋白重复域(3) SH3 and multiple ankyrin repeat domain;SHANK ★蛋白磷酸酶1调节亚基9(2) protein phosphatase 1 regulatory subunit 9;PPP1R9 ★高尔基体重新组装堆叠蛋白(2) golgi reassembly stacking protein;GORASP ★谷氨酸受体作用蛋白(2) glutamate receptor interacting protein;GRIP 互生蛋白?(2) syntrophin 膜关联鸟苷酸激酶,PDZ域(17) membrane associated guanylate kinase,PDZ domain ★黏结蛋白聚糖结合蛋白(2) syndecan binding protein;SDCBP ★散乱节段极性蛋白(3) dishevelled segment polarity protein;DVL ★微管关联丝氨酸/苏氨酸激酶(4) microtubule associated serine/threonine kinase;MAST 信号诱导增殖关联1样(3) signal induced proliferation associated 1 like AFDN afadin,黏合连接形成因子;afadin, adherens junction formation factor APBA1 淀粉样蛋白β前体蛋白结合家族A成员1;amyloid beta precursor protein binding family A member 1 APBA2 淀粉样蛋白β前体蛋白结合家族A成员2;amyloid beta precursor protein binding family A member 2 APBA3 淀粉样蛋白β前体蛋白结合家族A成员3;amyloid beta precursor protein binding family A member 3 ARHGAP21 Rho-GTP酶激活蛋白21;Rho GTPase activating protein 21 ARHGAP23(1) Rho-GTP酶激活蛋白23;Rho GTPase activating protein 23 ARHGEF11 Rho鸟苷酸交换因子11;Rho guanine nucleotide exchange factor 11 ARHGEF12 Rho鸟苷酸交换因子12;Rho guanine nucleotide exchange factor 12 CNKSR1 Ras激酶抑制物的连接增强物1;connector enhancer of kinase suppressor of Ras 1 CNKSR2 Ras激酶抑制物的连接增强物2;connector enhancer of kinase suppressor of Ras 2 CNKSR3 CNKSR家族成员3;CNKSR family member 3 CYTIP 胞粘蛋白?1作用蛋白;cytohesin 1 interacting protein DEPTOR DEP域MTOR作用蛋白;DEP domain containing MTOR interacting protein ERBIN erbb2作用蛋白;erbb2 interacting protein GOPC 高尔基体关联PDZ和卷曲螺旋基序;golgi associated PDZ and coiled-coil motif containing GRID2IP Grid2作用蛋白;Grid2 interacting protein IL16 白细胞介素16;interleukin 16 INTU 翻转平面细胞极性蛋白;inturned planar cell polarity protein LMO7 LIM域7;LIM domain 7 LRRC7 富含亮氨酸重复7;leucine rich repeat containing 7 MAGIX MAGI家族成员,X-连锁;MAGI family member, X-linked MPDZ 多PDZ域crumbs细胞极性复合体组分;multiple PDZ domain crumbs cell polarity complex component MYO18A 肌球蛋白XVIIIA;myosin XVIIIA NOS1 一氧化氮合酶1;nitric oxide synthase 1 PARD3 par-3家族细胞极性调节物;par-3 family cell polarity regulator PARD3B par-3家族细胞极性调节物β;par-3 family cell polarity regulator beta PATJ PATJ crumbs细胞极性复合体组分;PATJ crumbs cell polarity complex component PCLO 短笛突触前细胞基质蛋白;piccolo presynaptic cytomatrix protein PDZD11 PDZ域11;PDZ domain containing 11 PDZD2 PDZ域2;PDZ domain containing 2 PDZD4 PDZ域4;PDZ domain containing 4 PDZD7 PDZ域7;PDZ domain containing 7 PDZD8 PDZ域8;PDZ domain containing 8 PDZD9 PDZ域9;PDZ domain containing 9 PICK1 与PRKCA作用蛋白1;protein interacting with PRKCA 1 PREX1 磷脂酰肌醇-3,4,5-三磷酸依赖性Rac交换因子1;phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 PREX2 磷脂酰肌醇-3,4,5-三磷酸依赖性Rac交换因子2;phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 PRX 轴周蛋白;periaxin PSMD9 蛋白酶体26S亚基,非ATP酶9;proteasome 26S subunit, non-ATPase 9 PTPN13 蛋白酪氨酸磷酸酶非受体型13;protein tyrosine phosphatase non-receptor type 13 PTPN3 蛋白酪氨酸磷酸酶非受体型3;protein tyrosine phosphatase non-receptor type 3 PTPN4 蛋白酪氨酸磷酸酶非受体型4;protein tyrosine phosphatase non-receptor type 4 RADIL Rap,DIL域关联;Rap associating with DIL domain RAPGEF2 Rap鸟苷酸交换因子2;Rap guanine nucleotide exchange factor 2 RAPGEF6 Rap鸟苷酸交换因子6;Rap guanine nucleotide exchange factor 6 RGS12 G蛋白信号调节物12;regulator of G protein signaling 12 RGS3 G蛋白信号调节物3;regulator of G protein signaling 3 RHPN1 Rho结合蛋白,Rho-GTP酶结合蛋白1;rhophilin Rho GTPase binding protein 1 RHPN2(1) Rho结合蛋白,Rho-GTP酶结合蛋白2;rhophilin Rho GTPase binding protein 2 RIMS1 突触膜胞吐作用调节1;regulating synaptic membrane exocytosis 1 RIMS2 突触膜胞吐作用调节2;regulating synaptic membrane exocytosis 2 SCRIB 涂鸦平面细胞极性蛋白;scribble planar cell polarity protein SHROOM2(1) shroom家族成员2;shroom family member 2 SHROOM3 shroom家族成员3;shroom family member 3 SHROOM4 shroom家族成员4;shroom family member 4 SIPA1 信号-诱导增殖-关联1;signal-induced proliferation-associated 1 SNTA1 互生蛋白?α1;syntrophin alpha 1 SNX27 分选微管连接蛋白27;sorting nexin 27 STXBP4 突触融合蛋白结合蛋白4;syntaxin binding protein 4 SYNJ2BP synaptojanin-2结合蛋白;synaptojanin 2 binding protein SYNPO2 突触足蛋白2;synaptopodin 2 SYNPO2L 突触足蛋白2样;synaptopodin 2 like TAMALIN 运输调节物和支架蛋白tamalin;trafficking regulator and scaffold protein tamalin TAX1BP3 Tax1结合蛋白3;Tax1 binding protein 3 TIAM1 TIAM,Rac1关联GEF-1;TIAM Rac1 associated GEF 1 TIAM2 TIAM,Rac1关联GEF-2;TIAM Rac1 associated GEF 2 USH1C USH1蛋白网络组分协调蛋白?;USH1 protein network component harmonin WHRN whirlin FRMPD2B FERM和PDZ域2B (假基因);FERM and PDZ domain containing 2B (pseudogene) PDZPH1P PDZ和pleckstrin同源域1,假基因;PDZ and pleckstrin homology domains 1, pseudogene
简介
The PDZ domain is a common structural domain of 80-90 amino-acids found in the signaling proteins of bacteria, yeast, plants, viruses and animals. Proteins containing PDZ domains play a key role in anchoring receptor proteins in the membrane to cytoskeletal components. PDZ is an acronym combining the first letters of three proteins a€” post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) a€” which were first discovered to share the domain. PDZ domains have previously been referred to as DHR (Dlg homologous region) or GLGF ( glycine - leucine -glycine- phenylalanine ) domains. Proteins with these domains help hold together and organize signaling complexes at cellular membranes. Protein domains, connected by intrinsically disordered flexible linker regions, induce long-range allostery via protein domain dynamics. PDZ domains also play a highly significant role in the anchoring of cell surface receptors (such as CFTR and FZD7 ) to the actin cytoskeleton via mediators like NHERF and ezrin.
In general PDZ domains bind to a short region of the C-terminus of other specific proteins. These short regions bind to the PDZ domain by beta sheet augmentation. This means that the beta sheet in the PDZ domain is extended by the addition of a further beta strand from the tail of the binding partner protein.