RGS3

This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]
Diseases associated with RGS3 include Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are GPCR downstream signalling and EphB-EphrinB Signaling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS12.
Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form.
Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.
negative regulator of G protein signaling 3,functioning as GTPase-activating protein for G protein alpha i and q subunits,expressed in heart,skeletal muscle,lung and other tissues,C elegans EGL-10 and yeast SST2 homolog
Cytoplasm {ECO:0000269 PubMed:9858594}5
Nucleus {ECO:0000269 PubMed:10749886}5
Cell membrane; Peripheral membrane protein {ECO:0000269 PubMed:9858594}
Note: Long isoforms are cytoplasmic and associated with the plasma membrane (PubMed:9858594). Short isoforms are nuclear (PubMed:10749886).
Quaternary structure:
Binds EFNB1 and EFNB2 (By similarity).
Binds the GNB1-GNG2 heterodimer.