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词条

TLC域

ID: 70491 添加时间: 2024/7/23 0:18:57 修改时间: 2025/3/12 2:13:12 词条编辑: 刘小见
同义词TLC domain containing
层次树 人类基因组 域和家族
外库HGNC组  
父-分类
子-分类
  • CERS型同源盒(3)     CERS class homeoboxes;CERS
    ★TLC域3(2)     TLC domain 3;TLCD3
    ★易位关联膜蛋白1(2)     translocation associated membrane protein 1;TRAM1
    CLN8     CLN8跨膜内质网和ERGIC蛋白;CLN8 transmembrane ER and ERGIC protein
    TLCD1     TLC域1;TLC domain containing 1
    TLCD2     TLC域2;TLC domain containing 2
    TLCD4     TLC域4;TLC domain containing 4
    TLCD5     TLC域5;TLC domain containing 5
    TRAM2     易位关联膜蛋白2;translocation associated membrane protein 2
简介
The TLC domain is also known as the TRAM/LAG1/CLN8 homology domain (IPR006634). InterPro describes the domain and family members as follows: TLC is a protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p [yeast proteins] are essential for acyl-CoA-dependent ceramide synthesis [PMID: 11694577], TRAM1 is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. Proteins containing this domain may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues [e.g. the CERS class homeobox class family in humans] possess additional homeobox domains [PMID: 9872981].