★AKT激酶(3) AKT kinases ArfGAP含RhoGAP域,锚蛋白重复和PH域(3) ArfGAP with RhoGAP domain, ankyrin repeat and PH domain;ARAP ★ArfGAP含双PH域1/2(2) ArfGAP with dual PH domains 1/2 Fermitins(3) Fermitins;FERMT ★FYVE,RhoGEF和PH域5/6(2) FYVE,RhoGEF and PH domain 5/6;FGD5/6 GRB2关联结合蛋白(4) GRB2 associated binding protein ★G蛋白偶联受体激酶2/3(2) G protein-coupled receptor kinase 2/3;GRK2/3 PH域RhoGAP(5) pleckstrin homology domain RhoGAP PH域RhoGEF(13) pleckstrin homology domain RhoGEF ★PH域和富含亮氨酸重复蛋白磷酸酶(2) PH domain and leucine rich repeat protein phosphatase;PHLPP ★PH域内吞运输衔接蛋白(2) PH domain containing endocytic trafficking adaptor;PHETA ★Pleckstrin和Sec7域(4) Pleckstrin and Sec7 domain containing;PSD ★pleckstrin同源,MyTH4和FERM域H(3) pleckstrin homology, MyTH4 and FERM domain H;PLEKHH ★pleckstrin同源和FYVE域(2) pleckstrin homology and FYVE domain;PLEKHF ★pleckstrin同源域A1/2(2) pleckstrin homology domain A1/2;PLEKHA1/2 ★pleckstrin同源域A4/5/6/7(4) pleckstrin homology domain A4/5/6/7;PLEKHA4/5/6/7 ★pleckstrin同源域B(2) pleckstrin homology domain B;PLEKHB ★pleckstrin同源域O(2) pleckstrin homology domain O;PLEKHO ★rhotekin(2) rhotekin;RTKN ★SET结合因子(2) SET binding factor;SBF ★SH2B衔接蛋白(3) SH2B adaptor protein;SH2B ★SOS,Ras/Rac鸟苷酸交换因子(2) SOS Ras/Rac guanine nucleotide exchange factor ★vav鸟苷酸交换因子(3) vav guanine nucleotide exchange factor ★胞粘蛋白?(4) Cytohesins;CYTH ★蛋白激酶D(3) protein kinase D;PRKD ★发动蛋白1/3(2) dynamin 1/3;DNM1/3 ★钙依赖性分泌激活物(2) calcium dependent secretion activator;CADPS ★肌动蛋白丝关联蛋白1样(2) actin filament associated protein 1 like;AFAP1L ★血小板白细胞C激酶底物(2) pleckstrin;PLEK ★血影蛋白β,非红细胞(4) spectrin beta, non-erythrocytic;SPTBN ★转换?关联蛋白70(2) switch-associated protein 70 ABR ABR,RhoGEF和GTP酶激活物;ABR activator of RhoGEF and GTPase AFAP1 肌动蛋白丝关联蛋白1;actin filament associated protein 1 AKAP13 A-激酶锚蛋白13;A-kinase anchoring protein 13 ANLN anillin,肌动蛋白结合蛋白;anillin, actin binding protein APBB1IP 淀粉样蛋白β前体蛋白结合家族B成员1作用蛋白;amyloid beta precursor protein binding family B member 1 interacting protein BCR(9) BCR,RhoGEF和GTP酶激活物;BCR activator of RhoGEF and GTPase BMX BMX非受体酪氨酸激酶;BMX non-receptor tyrosine kinase BTK Bruton酪氨酸激酶;Bruton tyrosine kinase CDC42BPG CDC42结合蛋白激酶γ;CDC42 binding protein kinase gamma CERT1 神经酰胺转运蛋白1;ceramide transporter 1 CNKSR1 Ras激酶抑制物的连接增强物1;connector enhancer of kinase suppressor of Ras 1 CNKSR2 Ras激酶抑制物的连接增强物2;connector enhancer of kinase suppressor of Ras 2 DAPP1 磷酸酪氨酸和3-磷酸肌醇磷脂双衔接蛋白1;dual adaptor of phosphotyrosine and 3-phosphoinositides 1 DGKD 二酰甘油激酶δ;diacylglycerol kinase delta DGKH 二酰甘油激酶η;diacylglycerol kinase eta DNM2 发动蛋白2;dynamin 2 DOCK10 胞质分裂奉献者10;dedicator of cytokinesis 10 DOCK11(1) 胞质分裂贡献者11;dedicator of cytokinesis 11 DOCK9 胞质分裂贡献者9;dedicator of cytokinesis 9 DOK4 停泊蛋白4;docking protein 4 DOK5 停泊蛋白5;docking protein 5 DOK6 停泊蛋白6;docking protein 6 EXOC8 胞吐复合体组分8;exocyst complex component 8 FARP1 FERM,ARH/RhoGEF和pleckstrin域蛋白1;FERM, ARH/RhoGEF and pleckstrin domain protein 1 FARP2 FERM,ARH/RhoGEF和pleckstrin域蛋白2;FERM, ARH/RhoGEF and pleckstrin domain protein 2 FGD1 FYVE,RhoGEF和PH域1;FYVE, RhoGEF and PH domain containing 1 FGD2 FYVE,RhoGEF和PH域2;FYVE, RhoGEF and PH domain containing 2 FGD3 FYVE,RhoGEF和PH域3;FYVE, RhoGEF and PH domain containing 3 FGD4 FYVE,RhoGEF和PH域4;FYVE, RhoGEF and PH domain containing 4 GRB10 生长因子受体结合蛋白10;growth factor receptor bound protein 10 GRB14 生长因子受体结合蛋白14;growth factor receptor bound protein 14 GRB7 生长因子受体结合蛋白7;growth factor receptor bound protein 7 IPCEF1 胞粘蛋白?交换因子作用蛋白1;interaction protein for cytohesin exchange factors 1 IRS1 胰岛素受体底物1;insulin receptor substrate 1 IRS2 胰岛素受体底物2;insulin receptor substrate 2 ITK IL2诱导型T细胞激酶;IL2 inducible T cell kinase ITSN1 交叉蛋白?1;intersectin 1 KIF1A 驱动蛋白家族成员1A;kinesin family member 1A KIF1B 驱动蛋白家族成员1B;kinesin family member 1B MCF2L MCF.2细胞系源性转化序列样;MCF.2 cell line derived transforming sequence like MPRIP(1) 肌球蛋白磷酸酶Rho作用蛋白;myosin phosphatase Rho interacting protein MYO10 肌球蛋白X;myosin X NET1 神经上皮细胞转化1;neuroepithelial cell transforming 1;ARHGEF8 OSBP 氧化固醇结合蛋白;oxysterol binding protein OSBP2 氧化固醇结合蛋白2;oxysterol binding protein 2 OSBPL10 氧化固醇结合蛋白样10;oxysterol binding protein like 10 OSBPL11 氧化固醇结合蛋白样11;oxysterol binding protein like 11 OSBPL3 氧化固醇结合蛋白样3;oxysterol binding protein like 3 OSBPL5 氧化固醇结合蛋白样5;oxysterol binding protein like 5 OSBPL7 氧化固醇结合蛋白样7;oxysterol binding protein like 7 OSBPL8 氧化固醇结合蛋白样8;oxysterol binding protein like 8 OSBPL9(6) 氧化固醇结合蛋白样9;oxysterol binding protein like 9 PLCG1 磷脂酶Cγ1;phospholipase C gamma 1 PLD1 磷脂酶D1;phospholipase D1 PLEKHA3(1) pleckstrin同源域A3;pleckstrin homology domain containing A3 PLEKHA8(1) pleckstrin同源域A8;pleckstrin homology domain containing A8 PLEKHD1 pleckstrin同源和卷曲螺旋域D1;pleckstrin homology and coiled-coil domain containing D1 PLEKHJ1 pleckstrin同源域J1;pleckstrin homology domain containing J1 PLEKHM1(1) pleckstrin同源和RUN域M1;pleckstrin homology and RUN domain containing M1 PLEKHM2 pleckstrin同源和RUN域M2;pleckstrin homology and RUN domain containing M2 PLEKHM3 pleckstrin同源域M3;pleckstrin homology domain containing M3 PLEKHN1 pleckstrin同源域N1;pleckstrin homology domain containing N1 PLEKHS1 pleckstrin同源域S1;pleckstrin homology domain containing S1 PREX1 磷脂酰肌醇-3,4,5-三磷酸依赖性Rac交换因子1;phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 RALGPS1 Ral GEF含PH域和SH3结合基序1;Ral GEF with PH domain and SH3 binding motif 1 RALGPS2 Ral GEF含PH域和SH3结合基序2;Ral GEF with PH domain and SH3 binding motif 2 RAPH1 Ras关联(RalGDS/AF-6)和普列克底物蛋白同源域1;Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 RASA1 RAS p21蛋白激活物1;RAS p21 protein activator 1 RASA2 RAS p21蛋白激活物2;RAS p21 protein activator 2 RASA3 RAS p21蛋白激活物3;RAS p21 protein activator 3 RASA4B RAS p21蛋白激活物4B;RAS p21 protein activator 4B RASAL1 RAS蛋白激活物样1;RAS protein activator like 1 RASAL2 RAS蛋白激活物样2;RAS protein activator like 2 RASGRF1 Ras蛋白特异性鸟苷酸释放因子1;Ras protein specific guanine nucleotide releasing factor 1 RASGRF2 Ras蛋白特异性鸟苷酸释放因子2;Ras protein specific guanine nucleotide releasing factor 2 ROCK1(1) Rho关联卷曲螺旋蛋白激酶1;Rho associated coiled-coil containing protein kinase 1 ROCK2 Rho关联卷曲螺旋蛋白激酶2;Rho associated coiled-coil containing protein kinase 2 SH3BP2 SH3域结合蛋白2;SH3 domain binding protein 2 SKAP1 src激酶关联磷蛋白1;src kinase associated phosphoprotein 1 SKAP2 src激酶关联磷蛋白2;src kinase associated phosphoprotein 2 SNTB1 互生蛋白?β1;syntrophin beta 1 SPTB 血影蛋白β,红细胞;spectrin beta, erythrocytic TEC tec蛋白酪氨酸激酶;tec protein tyrosine kinase TIAM1 TIAM,Rac1关联GEF-1;TIAM Rac1 associated GEF 1 TIAM2 TIAM,Rac1关联GEF-2;TIAM Rac1 associated GEF 2 TRIOBP TRIO和F-肌动蛋白结合蛋白;TRIO and F-actin binding protein VEPH1 脑室区表达PH域1;ventricular zone expressed PH domain containing 1
简介
Pleckstrin homology domain (PH domain) is a protein domain of approximately 120 amino acids that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.
This domain can bind Phosphatidylinositol lipids within biological membranes (such as Phosphatidylinositol (3,4,5)-trisphosphate and phosphatidylinositol (4,5)-bisphosphate ), and proteins such as the Betagamma-subunits of heterotrimeric G proteins, and protein kinase C. Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways.