| 简介 | The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008]
Diseases associated with VAPB include Amyotrophic Lateral Sclerosis 8 and Spinal Muscular Atrophy, Late-Onset, Finkel Type. Among its related pathways are Signaling by Rho GTPases and RHOC GTPase cycle. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is VAPA.
Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, 33124732).
Interacts with STARD3 in a FFAT motif phosphorylation dependent manner (PubMed:33124732).
Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433).
Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity (PubMed:16891305, 20940299).
Involved in cellular calcium homeostasis regulation (PubMed:22131369).
Endoplasmic reticulum membrane; Single-pass type IV membrane protein {ECO:0000269 PubMed:32344433, 33124732 | ECO:0000250 UniProtKB:Q9P0L0}
Note: Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane {ECO:0000269 PubMed:22131369}
Quaternary structure:
Homodimer, and heterodimer with VAPA (PubMed:20940299).
Interacts with VAMP1 and VAMP2 (PubMed:20940299, 9920726).
Interacts (via MSP domain) with ZFYVE27 (PubMed:19289470, 21976701).
Interacts with RMDN3 (PubMed:22131369).
Interacts with KIF5A in a ZFYVE27-dependent manner (PubMed:21976701).
Interacts (via MSP domain) with STARD3 (via phospho-FFAT motif) (PubMed:24105263, 33124732).
Interacts with STARD3NL (via FFAT motif) (PubMed:24105263).
Interacts with CERT1 (PubMed:16895911).
Interacts with PLEKHA3 and SACM1L to form a ternary complex (PubMed:30659099).
Interacts with VPS13A (via FFAT motif) (PubMed:30741634).
Interacts with RB1CC1 (via phosphorylated FFAT motif), MIGA2 (via phosphorylated FFAT motif), RMDN3 (via phosphorylated FFAT motif), OSBPL1A (via FFAT motif), KCNB1 (via phosphorylated FFAT motif) and KCNB2 (via phosphorylated FFAT motif) (PubMed:33124732).
Interacts (via MSP domain) with WDR44 (via FFAT motif); the interactions connect the endoplasmic reticulum (ER) with the endosomal tubule (PubMed:32344433).
(Microbial infection) Interacts (via MSP domain) with hepatitis C virus (HCV) non-structural protein 5A (via disordered domain D3) (PubMed:16227268, 22720086).
Interacts with HCV RNA-directed RNA polymerase (PubMed:16227268). |
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