| 简介 | This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2017]
Diseases associated with TKFC include Triokinase And Fmn Cyclase Deficiency Syndrome and Sengers Syndrome. Among its related pathways are SARS-CoV-2 Infection and Infectious disease. Gene Ontology (GO) annotations related to this gene include glycerone kinase activity and triokinase activity.
Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate.
Represses IFIH1-mediated cellular antiviral response (PubMed:17600090).
cytosol 5
nucleus 5
Quaternary structure:
Homodimer (By similarity).
Interacts with IFIH1 (via the CARD domains), the interaction is inhibited by viral infection (PubMed:17600090). |
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