Predicted to enable GTPase activator activity. Acts upstream of or within cell migration. Predicted to be located in cytosol. Predicted to be active in synaptic membrane. [provided by Alliance of Genome Resources, Nov 2024] Diseases associated with SYDE2 include Chondrodysplasia, Blomstrand Type and Spherocytosis, Type 1. Among its related pathways are Signaling by Rho GTPases and RAC1 GTPase cycle. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is SYDE1. GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. cytosol 5