| 简介 | Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008]
Diseases associated with SLN include Brody Disease and Atrial Fibrillation. Among its related pathways are Cardiac conduction and Ion channel transport. Gene Ontology (GO) annotations related to this gene include ATPase binding and enzyme regulator activity.
Reversibly inhibits the activity of ATP2A1 and ATP2A2 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+).
Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle.
Required for muscle-based, non-shivering thermogenesis (By similarity).
sarcolipin,low molecular weight proteolipid associated with the fast-twitch skeletal muscle sarcoplasmic reticulum Ca++ ATPase (ATP2A1),phospholamban homolog
Sarcoplasmic reticulum membrane; Single-pass membrane protein {ECO:0000269 PubMed:11781085, 9575189 | ECO:0000255}
Endoplasmic reticulum membrane; Single-pass membrane protein {ECO:0000250 UniProtKB:P42532}5
Quaternary structure:
Interacts with calcium ATPase ATP2A1/SERCA1.
Interact with ATP2A2; the inhibition decreases ATP2A1 Ca(2+) affinity (PubMed:28890335).
Interacts with VMP1; VMP1 competes with PLN and SLN to prevent them from forming an inhibitory complex with ATP2A2 (PubMed:28890335). |
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