| 简介 | Riboflavin kinase (RFK; EC 2.7.1.26) is an essential enzyme that catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN), an obligatory step in vitamin B2 utilization and flavin cofactor synthesis (Karthikeyan et al., 2003 [PubMed 12623014]).[supplied by OMIM, Nov 2009]
Diseases associated with RFK include Riboflavin Deficiency and Brown-Vialetto-Van Laere Syndrome. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and flavin biosynthesis. Gene Ontology (GO) annotations related to this gene include riboflavin kinase activity.
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD.
Essential for TNF-induced reactive oxygen species (ROS) production.
Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase.
TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.
Cytoplasm {ECO:0000250}5
Quaternary structure:
Monomer.
Directly interacts with TNFRSF1A death domain.
TNFRSF1A-binding may be supported by TRADD.
In the absence of TNFRSF1A, interacts with TRADD.
Independently of TNFRSF1A, interacts with the NADPH oxidase subunit CYBA. |
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