| 简介 | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Oct 2015]
Diseases associated with PTPRE include Familial Hemophagocytic Lymphohistiocytosis 5. Among its related pathways are PAK Pathway and IL6-mediated signaling events. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRA.
Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells.
May play a role in osteoclast formation and function (By similarity).
Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle.
Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity).
Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).
Up-regulated by 12-O-tetradecanoylphorbol-13-acetate (TPA) in HL-60 cells.
protein tyrosine phosphatase,receptor-type IV,epsilon polypeptide
[Isoform 1]
Cell membrane; Single-pass type I membrane protein 5
[Isoform 2]
Cytoplasm 1
Note: Predominantly cytoplasmic. A small fraction is also associated with nucleus and membrane. Insulin induces translocation to the membrane (By similarity) {ECO:0000250}
[Isoform 3]
Cytoplasm 1
Quaternary structure:
Monomer.
Isoform 2: Homodimer.
Can form oligomers.
Dimerization is increased by oxidative stress and decreased by EGFR.
Isoform 2 interacts with GRB2 (By similarity). |
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