| 简介 | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Diseases associated with PTPRA include Dystonia 30 and Common Peroneal Nerve Lesion. Among its related pathways are Activation of cAMP-Dependent PKA and MAPK family signaling cascades. Gene Ontology (GO) annotations related to this gene include phosphatase activity and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRE.
Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity).
Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity).
protein tyrosine phosphatase,receptor-type IV,alpha polypeptide
Cell membrane; Single-pass type I membrane protein {ECO:0000255}5
Cell junction, focal adhesion {ECO:0000250 UniProtKB:P18052}
Note: Localizes to focal adhesion sites following integrin engagement {ECO:0000250 UniProtKB:P18052}
Quaternary structure:
Part of a complex comprised of PTPRA, BCAR1, BCAR3 (via SH2 domain), and SRC (PubMed:22801373).
Within the complex, interacts (when phosphorylated on Tyr-798) with BCAR3 (via SH2 domain) (PubMed:22801373).
Interacts with GRB2 (PubMed:22801373). |
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