| 简介 | The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]
Diseases associated with PIK3C2B include Occlusion Of Gallbladder and Myopathy, Centronuclear, X-Linked. Among its related pathways are PI Metabolism and NF-kappaB Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is PIK3C2A.
Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns (PubMed:10805725, 11533253, 9830063).
Does not phosphorylate PtdIns(4,5)P2 (PubMed:9830063).
May be involved in EGF and PDGF signaling cascades (PubMed:10805725).
Activated by GRB2.
phosphatidylinositol 3-kinase,class 2,widely expressed
Microsome {ECO:0000269 PubMed:14563213, 9830063}
Cell membrane {ECO:0000269 PubMed:14563213, 9830063}5
Cytoplasm, cytosol {ECO:0000269 PubMed:14563213, 9830063}5
Nucleus {ECO:0000269 PubMed:14563213}5
Endoplasmic reticulum {ECO:0000269 PubMed:14563213}4
Note: Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis.
Quaternary structure:
Part of a complex with ERBB2 and EGFR.
Part of a complex with phosphorylated EGFR and GRB2.
Interacts with phosphorylated EGFR and PDGFR, maybe indirectly.
Interacts with GRB2. |
|---|