| 简介 | Enables 1-phosphatidylinositol 4-kinase activity and 14-3-3 protein binding activity. Involved in inner ear development. Acts upstream of or within lysosome organization. Located in Golgi membrane. Implicated in autosomal dominant nonsyndromic deafness. [provided by Alliance of Genome Resources, Nov 2024]
Diseases associated with PI4KB include Deafness, Autosomal Dominant 87 and Enlarged Vestibular Aqueduct. Among its related pathways are Metabolism and PI Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and 1-phosphatidylinositol 4-kinase activity. An important paralog of this gene is PI4KA.
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP).
May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation.
Involved in Golgi-to-plasma membrane trafficking (By similarity) (PubMed:10559940, 11277933, 12749687, 9405935).
May play an important role in the inner ear development.
Inhibited by wortmannin and adenosine (PubMed:11277933).
Increased kinase activity upon interaction with NCS1/FREQ (By similarity).
novel putative phosphatidylinositol 4-kinase,catalytic,beta polypeptide,93kDa,cytoplasmic,ubiquitously expressed,with two alternatively spliced isoforms,yeast PIK1 homolog,involved in the biosynthesis of membrane phosphoinositides
Endomembrane system 4
Mitochondrion outer membrane; Peripheral membrane protein4
Rough endoplasmic reticulum membrane; Peripheral membrane protein 4
Golgi apparatus {ECO:0000269 PubMed:22124328}5
Golgi apparatus membrane {ECO:0000269 PubMed:24672044, 27009356, 28289207}
Cytoplasm, perinuclear region 5
Note: Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. Recruited to the Golgi apparatus membrane by ACBD3 (PubMed:24672044, 27009356, 28289207). GGA2 is also involved in the recruitment (PubMed:28289207) {ECO:0000269 PubMed:24672044, 27009356, 28289207}
Quaternary structure:
Interacts with ARF1 and ARF3 in the Golgi complex, but not with ARF4, ARF5 or ARF6 (PubMed:17555535).
Interacts with NCS1/FREQ in a calcium-independent manner.
Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner; this interaction competes with NCS1/FREQ binding (By similarity).
Interacts with ACBD3 (PubMed:22124328, 22258260, 23572552, 27009356, 27989622).
Interacts with ARMH3, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN (PubMed:23572552).
Interacts with GGA2 (via VHS domain); the interaction is important for PI4KB location at the Golgi apparatus membrane (PubMed:28289207).
Interacts with ATG9A (PubMed:30917996). |
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