| 简介 | Predicted to enable phosphatidylinositol binding activity. Acts upstream of or within negative regulation of JUN kinase activity. Predicted to be located in cytoplasm. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Gene Ontology (GO) annotations related to this gene include protein domain specific binding.
Acts as a ventralizing factor during embryogenesis.
Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization.
This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).
Quaternary structure:
Interacts with AXIN1. |
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