| 简介 | This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Diseases associated with KHK include Fructosuria, Essential and Basidiobolomycosis. Among its related pathways are Fructose metabolism and Uric Acid-Lowering Drugs Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include fructokinase activity and ketohexokinase activity. An important paralog of this gene is ADK.
Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate.
Requires potassium.
Inhibition by ADP.
ketohexokinase,fructose metabolism,energy pathway,expressed in liver,renal cortex and small intestine
cytosol 5
extracellular 5
Quaternary structure:
Homodimer. |
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