IPMK

This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010]
Diseases associated with IPMK include Hereditary Neuroendocrine Tumor Of Small Intestine and Multiple Endocrine Neoplasia. Among its related pathways are Inositol phosphate metabolism and superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism. Gene Ontology (GO) annotations related to this gene include inositol-1,4,5-trisphosphate 3-kinase activity and inositol-1,4,5,6-tetrakisphosphate 3-kinase activity. An important paralog of this gene is IP6K1.
Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, 12223481, 28882892, 30420721, 30624931).
Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:12027805, 12223481, 28882892, 30624931).
Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12223481).
Phosphorylates inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4) (By similarity).
Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (PubMed:28882892, 30420721).
Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6).
Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase.
Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610).
Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity).
Inhibited by flavonoids that occupy the ATP-binding pocket.
Inhibited by myricetin, quercetin, luteolin, kaempferol, isorhamnetin and diosmetin, and to a lesser degree by rhamnetin and apigenin.
Nucleus {ECO:0000269 PubMed:12027805}5