| 简介 | This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR. [provided by RefSeq, Sep 2008]
Diseases associated with HRC include Coronary Artery Disease, Autosomal Dominant, 1 and Transvestism. Among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include calcium ion binding and ATPase binding.
May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle.
histidine-rich calcium binding protein (sarcoplasmic reticulum,luminal)
Sarcoplasmic reticulum lumen |
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