Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; negative regulation of sodium ion transmembrane transporter activity; and regulation of dendrite morphogenesis. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Diseases associated with HECW1 include Spermatogenic Failure 59 and Lung Papillary Adenocarcinoma. Among its related pathways are Signaling by WNT and Regulation of activated PAK-2p34 by proteasome mediated degradation. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is HECW2. E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. cDNA sequence,expressed in brain,>100kDa,related to rat ubiquitin ligase NEDD 4 Cytoplasm {ECO:0000269 PubMed:14684739} Quaternary structure: Interacts with DVL1 and SSR3. Also interacts with mutant SOD1.