| 简介 | A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way, fructosamines, are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of fructosamines which may result in deglycation. [provided by RefSeq, Feb 2012]
Diseases associated with FN3K include Presbyopia and Diabetes Mellitus. Among its related pathways are Metabolism of proteins and Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein-fructosamine 3-kinase activity. An important paralog of this gene is FN3KRP.
Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed:11016445, 11522682, 11975663).
Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:11522682, 11975663).
Involved in intracellular deglycation in erythrocytes (PubMed:11975663).
Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity).
Also able to phosphorylate psicosamines and ribulosamines (PubMed:14633848).
cytosol 5 |
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