| 简介 | This gene encodes a protein that phosphorylates carbohydrates such as ribulose, ribitol, and L-arabinitol. Genome-wide association studies in some populations have found an association between polymorphisms in this gene and sporadic amyotrophic lateral sclerosis, but studies of other populations have not been able to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Diseases associated with FGGY include Sporadic Amyotrophic Lateral Sclerosis and Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1. Gene Ontology (GO) annotations related to this gene include kinase activity and phosphotransferase activity, alcohol group as acceptor. An important paralog of this gene is GK.
Catalyzes ATP-dependent phosphorylation of D-ribulose at C-5 to form D-ribulose 5-phosphate.
Postulated to function in a metabolite repair mechanism by preventing toxic accumulation of free D-ribulose formed by non-specific phosphatase activities.
Alternatively, may play a role in regulating D-ribulose 5-phosphate recycling in the pentose phosphate pathway.
Can phosphorylate ribitol with low efficiency. |
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