| 简介 | CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]
Diseases associated with CERK include Retinitis Pigmentosa 26 and Retinitis Pigmentosa. Among its related pathways are Sphingolipid metabolism and Sphingolipid pathway. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and ATP-dependent diacylglycerol kinase activity. An important paralog of this gene is CERKL.
Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate (PubMed:11956206, 16269826, 19168031).
Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines (PubMed:11956206, 16269826, 19168031).
Shows a greater preference for D-erythro isomer of ceramides (PubMed:16269826).
Binds phosphoinositides (PubMed:19168031).
Inhibited by sulfatide (PubMed:19168031).
Inhibited by sphinganine, sphingenine, and N,N-Dimethylsphingosine (DMS) (PubMed:16269826).
Cardiolipin at 0.1 uM significantly increases activity, whereas at concentrations >1 uM has an inhibitory effect (PubMed:27725450).
Cytoplasm {ECO:0000269 PubMed:19168031}3
Cell membrane; Peripheral membrane protein {ECO:0000269 PubMed:16269826, 19168031, 19168031}5 |
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