| 简介 | The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011]
Diseases associated with CDT1 include Meier-Gorlin Syndrome 4 and Meier-Gorlin Syndrome 1. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Activation of the pre-replicative complex.
Required for both DNA replication and mitosis (PubMed:11125146, 14993212, 21856198, 22581055, 26842564).
DNA replication licensing factor, required for pre-replication complex assembly.
Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932).
Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055).
Potential oncogene (By similarity).
Induced by E2F transcription factors (PubMed:14990995).
Nucleus {ECO:0000269 PubMed:11125146, 26842564}
Chromosome, centromere, kinetochore {ECO:0000269 PubMed:22581055}
Note: Transiently localizes to kinetochores during prometaphase and metaphase {ECO:0000269 PubMed:22581055}
Quaternary structure:
Interacts with GMNN; the interaction inhibits binding of the MCM complex to origins of replication (PubMed:11125146, 14672932, 14993212, 15257290).
Interacts with MCM6 (By similarity).
Interacts with CDC6; are mutually dependent on one another for loading MCM complexes onto chromatin (PubMed:14672932).
Interacts with PCNA (PubMed:16861906).
Interacts with LRWD1 during G1 phase and during mitosis (PubMed:22645314).
Interacts with NDC80 subunit of the NDC80 complex; leading to kinetochore localization (PubMed:22581055).
Interacts with GRWD1; origin binding of GRWD1 is dependent on CDT1 (PubMed:25990725).
Interacts with KAT7 (PubMed:18832067).
Interacts with ubiquitin-binding protein FAF1; the interaction is likely to promote CDT1 degradation (PubMed:26842564). |
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