| 简介 | Enables calcium ion binding activity and calcium-dependent phospholipid binding activity. Involved in several processes, including insulin receptor signaling pathway; intracellular protein transmembrane transport; and positive regulation of protein targeting to membrane. Located in several cellular components, including centriolar satellite; cytoplasmic vesicle membrane; and ruffle membrane. [provided by Alliance of Genome Resources, Nov 2024]
Diseases associated with C2CD5 include Protoplasmic Astrocytoma. Among its related pathways are Vesicle-mediated transport and Activation of AMPK downstream of NMDARs. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding.
Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes.
Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM.
Cytoplasmic vesicle membrane {ECO:0000269 PubMed:21907143}
Cytoplasm, cell cortex {ECO:0000269 PubMed:21907143}5
Cell membrane {ECO:0000269 PubMed:21907143}5
Cell projection, ruffle {ECO:0000269 PubMed:21907143}
Note: Dynamically associated with GLUT4-containing glucose storage vesicles (GSV) and plasma membrane in response to insulin stimulation. |
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