Involved in positive regulation of acute inflammatory response; regulation of cell adhesion; and regulation of vascular permeability involved in acute inflammatory response. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024] Diseases associated with C2CD4B include Maturity-Onset Diabetes Of The Young and Neonatal Diabetes. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is C2CD4A. May be involved in inflammatory process. May regulate cell architecture and adhesion. Up-regulated by pro-inflammatory cytokines. Nucleus {ECO:0000269 PubMed:15527968}5